The mu-opioid receptor is necessary for [D-Pen(2),D-Pen(5)]enkephalin-induced analgesia

被引：98

作者：

Sora, I

Funada, M

Uhl, GR

机构：

[1] NIDA,MOL NEUROBIOL BRANCH,IRP,BALTIMORE,MD 21224

[2] JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROL,BALTIMORE,MD 21205

[3] JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI,BALTIMORE,MD 21205

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1997年 / 324卷 / 2-3期

关键词：

DPDPE; ([D-Pen(2); D-Pen(5)]enkephalin); delta-opioid receptor; mu-opioid receptor knockout mouse;

D O I：

10.1016/S0014-2999(97)10016-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Interactions between delta-opioid receptors and morphine preferring mu-opioid receptor subtypes have been suggested. Availability of transgenic mu-opioid receptor knockout mice allows assessment of mu-opioid receptor roles in the analgesia produced by the classical delta-opioid receptor agonist [D-Pen(2),D-Pen(5)]enkephalin (DPDPE) in hot-plate and tail-flick tests. DPDPE analgesia was dramatically reduced in mu-opioid receptor knockout mice in a gene-dose-dependent fashion. The analgesia induced by this classic delta-opioid receptor agonist depends on intact mu-opioid receptors, suggesting that selective delta-opioid receptor drugs may require mu-opioid receptor occupancies for full efficacy.

引用

页码：R1 / R2

页数：2

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