Synthesis and in vitro activity of a series 1β-methylcarbapenem derivatives

被引：5
|
作者：
Jeon, H. C.
Kim, J. -W.
Hong, J. H.
Cho, J. -H.
Oh, C. -H.
机构：
[1] Korea Adv Inst Sci & Technol, Med Chem Res Ctr, Seoul 130650, South Korea
[2] Hanyang Univ, Dept Chem, Seoul 133791, South Korea
[3] Chosun Univ, Coll Pharm, Kwangju 501759, South Korea
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2006年 / 41卷 / 10期
关键词：
1; beta-methylcarbapenems; antibacterial activity; substituent effects;
D O I：
10.1016/j.ejmech.2006.05.003
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthesis of a new series of 1 beta-methylcarbapenems having pyrrolidine and piperidine moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituent on the pyrrolidine ring was investigated. A particular compound (IIIb) having hydroxypyrrolidine moiety showed the most potent antibacterial activity. (c) 2006 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：1201 / 1209
页数：9
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