Human respiratory syncytial virus reduces the number of cells in S-phase and increases GADD153 expression in HEp-2 cells

被引：4

作者：

Mohapatra, S. ^{[1
,2
]}

Park, S. J. ^{[2
]}

Boyapalle, S. ^{[2
]}

Pastey, M. K. ^{[3
]}

Graham, B. S. ^{[4
]}

Blanck, G. ^{[1
]}

机构：

[1] Univ S Florida, Coll Med, Joy McCann Culverhouse Airway Dis Ctr, Dept Mol Med,VA Hosp, Tampa, FL 33620 USA

[2] Univ S Florida, Coll Med, Joy McCann Culverhouse Airway Dis Ctr, Dept Internal Med,VA Hosp, Tampa, FL USA

[3] Oregon State Univ, Coll Vet Med, Dept Biomed Sci, Corvallis, OR 97331 USA

[4] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

来源：

ACTA VIROLOGICA | 2009年 / 53卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Human respiratory syncytial virus; cell cycle; S-phase; G1-phase; GADD153; US CHILDREN; DISEASE; RSV; INHIBITION; MECHANISMS; ASTHMA;

D O I：

10.4149/av_2009_03_207

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Human respiratory syncytial virus (HRSV) associated with bronchiolitis and asthma is known to replicate actively in ciliated epithelial cells. However, little is known about the influence of HRSV replication on the cell cycle. We found that HRSV infection of HEp-2 cells led to a reduction of the number ofcells in S-phase, to an increase in the number ofcells in G1-phase, together with an increase of GADD 153 mRNA levels and GADD153 protein expression. These results implied that a shorter S-phase supported HRSV replication suggesting possible strategies for interfering with productive HRSV infection.

引用

页码：207 / 211

页数：5

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