Determination of diclofenac in pharmaceutical preparations using a novel PVC membrane sensor

被引：0
|
作者：
Hassan, SSM [1 ]
Mahmoud, WH
Elmosallamy, MAF
Almarzooqi, MH
机构：
[1] Ain Shams Univ, Fac Sci, Dept Chem, Cairo, Egypt
[2] Zagazig Univ, Fac Sci, Dept Chem, Zagazig, Egypt
来源：
PHARMAZIE | 2003年 / 58卷 / 01期
关键词：
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A novel potentiometric PVC membrane sensor for determination of diclofenac: in pharmaceutical preparations has been developed. The sensor is based on the use of the 2,4,6-tri(2-pyridyl)-s-triazine iron(II) diclofenac complex [diclofenac-TPTZ-Fe(II)] as an electroactive material in a plasticized PVC membrane matrix. The sensor exhibits fast, stable and near Nernstian response for diclofenac over the concentration range 10(-2)-10(-6) M and pH 5.5-9.5. Application to quality control analysis of diclofenac in various dosage forms shows an average recovery of 99% with a mean standard deviation of 0.2%. No significant interferences are caused by inorganic and organic anions and various drug excipients and diluents.
引用
收藏
页码：29 / 31
页数：3
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