Palladium-catalyzed, aminoquinoline-directed arylation of phosphonamidate and phosphinic amide sp3 C-H bonds

被引：15

作者：

Tung Thanh Nguyen ^{[1
]}

Daugulis, Olafs ^{[1
]}

机构：

[1] Univ Houston, Dept Chem, Univ Pk, Houston, TX 77204 USA

来源：

CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 33期

关键词：

CARBON-HYDROGEN BONDS; CYCLIZATION; ACTIVATION; FUNCTIONALIZATION; ALKYLATION; PHENOLS; OXIDES; SP(2); SCOPE;

D O I：

10.1039/c7cc02063e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Aminoquinoline-directed, palladium-catalyzed sp(3) C-H bond arylation in phosphonamidates and phosphinic amides is reported. The reaction employs Pd(OAc)(2) as a catalyst at 10 mol% loading and cesium phosphate or potassium carbonate as a base in 1,2-dichlorobenzene as a solvent. The directing group can be removed under basic conditions to afford phosphonic acid esters. The chemistry described here is the first example of unactivated sp(3) C-H bond arylation by using a phosphorus-containing directing group.

引用

页码：4609 / 4611

页数：3

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