Synthesis, characterization and antimicrobial studies on 3-((4-(4-nitrophenyl)-6-aryl-1,6-dihydropyrimidin-2-yl)thio)propanenitriles and their derivatives

被引：5
|
作者：
Desai, N. C. [1 ]
Pandya, Darshan [1 ]
Vaja, Darshita [1 ]
机构：
[1] Maharaja Krishnakumarsinhji Bhavnagar Univ, Dept Chem, Div Med Chem, UGC NON SAP & DST FIST Sponsored, Mahatma Gandhi Campus, Bhavnagar 364002, Gujarat, India
来源：
MEDICINAL CHEMISTRY RESEARCH | 2017年 / 26卷 / 06期
关键词：
Pyrimidine; 1,6-dihydropyrimidine; Antimicrobial activity; Cytotoxicity; ANTI-HIV ACTIVITY; QUINOLINE; BENZIMIDAZOLES; PYRIMIDINE; AGENTS; 1,3,4-OXADIAZOLE;
D O I：
10.1007/s00044-017-1812-2
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
This study synthesized a series of 3-((4-(4-nitrophenyl)-6-aryl-1,6-dihydropyrimidin-2-yl)thio)propanenitriles and their structures characterized by spectral (H-1 NMR, C-13 NMR, infrared spectroscopy, liquid chromatography-mass spectroscopy) and elemental analysis. Antimicrobial activity was carried out by serial broth dilution method on gram-positive bacteria (Staphylococcus aureus and Streptococcus pyogenes), gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) and three fungi (Candida albicans, Aspergillus niger and Aspergillus clavatus) in vitro. Compounds 5d, 5j, 5l and 5m showed potent antimicrobial activity against tested microorganisms. The grades of cytotoxicity studies on a human cervical cancer cell line (HeLa) and a 3T3 mouse embryonic fibroblast cell line indicated that compounds 5c, 5d, 5h and 5j showed low cytotoxicity.
引用
收藏
页码：1089 / 1097
页数：9
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