Gastric Cancer Screening in First-Degree Relatives: A Pilot Study in a Diverse Integrated Healthcare System

被引：6
|
作者：
Dong, Elizabeth Y. Y. [1 ]
Giap, Andrew Q. [2 ]
Lustigova, Eva [3 ]
Wu, Bechien U. U. [1 ,3 ,4 ]
机构：
[1] Southern Calif Permanente Med Grp, Div Gastroenterol, Los Angeles, CA 90034 USA
[2] Southern Calif Permanente Med Grp, Div Gastroenterol, Anaheim, CA USA
[3] Southern Calif Permanente Med Grp, Dept Res & Evaluat, Pasadena, CA 90034 USA
[4] Southern Calif Med Grp, Div Gastroenterol, Ctr Pancreat Care, Los Angeles, CA 90034 USA
来源：
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY | 2022年 / 13卷 / 11期
关键词：
INTESTINAL METAPLASIA; RISK;
D O I：
10.14309/ctg.0000000000000531
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
INTRODUCTIONFamily history of gastric cancer has been shown as an independent risk factor of gastric cancer development and is associated with increased risk of progression to gastric cancer among patients with gastric intestinal metaplasia (GIM).METHODSBetween 2017 and 2020, we conducted a prospective pilot screening program of patients with a confirmed first-degree relative with gastric cancer to evaluate the feasibility of screening and prevalence of precursor lesions (e.g., GIM or dysplasia) on biopsy.RESULTSA total of 61 patients completed screening by upper endoscopy with a mapping biopsy protocol: 27 (44%) were found to have GIM and 4 (7%) were found with low-grade dysplasia.DISCUSSIONOur pilot screening program identified a high prevalence of precursor lesions for gastric cancer among asymptomatic patients with a first-degree relative with gastric cancer. Careful endoscopic inspection and standardized biopsy protocols may aid in prompt identification of these precursor lesions in those at risk of gastric cancer.
引用
收藏
页数：2
相关论文
共 50 条
  • [31] Participation in screening colonoscopy in first-degree relatives from patients with colorectal cancer
    Ruthotto, F.
    Papendorf, F.
    Wegener, G.
    Unger, G.
    Cilugosch, B.
    Korangy, F.
    Manns, M. P.
    Greten, T. F.
    ANNALS OF ONCOLOGY, 2007, 18 (09) : 1518 - 1522
  • [32] Effectiveness of a colonoscopic screening programme in first-degree relatives of patients with colorectal cancer
    Puente Gutierrez, J. J.
    Marin Moreno, M. A.
    Dominguez Jimenez, J. L.
    Bernal Blanco, E.
    Diaz Iglesias, J. M.
    COLORECTAL DISEASE, 2011, 13 (06) : E145 - E153
  • [33] Colorectal cancer screening in first-degree relatives of colorectal cancer: participation, knowledge, and barriers against screening
    Gimeno Garcia, Antonio Z.
    Quintero, Enrique
    Nicolas Perez, David
    Hernandez, Manuel
    Jimenez Sosa, Alejandro
    EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 2011, 23 (12) : 1165 - 1171
  • [34] Increased risk for uterine cancer among first-degree relatives to Swedish gastric cancer patients
    Johanna Samola Winnberg
    Eva Rudd
    Anne Keränen
    Kristina Lagerstedt-Robinson
    Annika Lindblom
    Magnus Nilsson
    Mats Lindblad
    Krister Sjödahl
    Hereditary Cancer in Clinical Practice, 18
  • [35] Increased risk for uterine cancer among first-degree relatives to Swedish gastric cancer patients
    Samola Winnberg, Johanna
    Rudd, Eva
    Keranen, Anne
    Lagerstedt-Robinson, Kristina
    Lindblom, Annika
    Nilsson, Magnus
    Lindblad, Mats
    Sjodahl, Krister
    HEREDITARY CANCER IN CLINICAL PRACTICE, 2020, 18 (01)
  • [36] Colonoscopic screening in first-degree relatives of patients with 'sporadic' colorectal cancer: A case-control study
    Pariente, A
    Milan, C
    Lafon, J
    Faivre, J
    GASTROENTEROLOGY, 1998, 115 (01) : 7 - 12
  • [37] Gastric dysmotility in healthy first-degree relatives of patients with schizophrenia
    Berger, Sandy
    Hocke, Michael
    Baer, Karl-Juergen
    PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2010, 34 (07): : 1294 - 1299
  • [38] Screening for Dilated Cardiomyopathy in At-Risk First-Degree Relatives
    Ni, Hanyu
    Jordan, Elizabeth
    Kinnamon, Daniel D.
    Cao, Jinwen
    Haas, Garrie J.
    Hofmeyer, Mark
    Kransdorf, Evan
    Ewald, Gregory A.
    Morris, Alanna A.
    Owens, Anjali
    Lowes, Brian
    Stoller, Douglas
    Tang, W. H. Wilson
    Garg, Sonia
    Trachtenberg, Barry H.
    Shah, Palak
    Pamboukian, Salpy V.
    Sweitzer, Nancy K.
    Wheeler, Matthew T.
    Wilcox, Jane E.
    Katz, Stuart
    Pan, Stephen
    Jimenez, Javier
    Fishbein, Daniel P.
    Smart, Frank
    Wang, Jessica
    Gottlieb, Stephen S.
    Judge, Daniel P.
    Moore, Charles K.
    Huggins, Gordon S.
    Hershberger, Ray E.
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2023, 81 (21) : 2059 - 2071
  • [39] Psychological distance: a qualitative study of screening barriers among first-degree relatives of colorectal cancer patients
    Xueying Zhang
    Yiheng Zhang
    Jingyu Chen
    Meifen Zhang
    Ni Gong
    BMC Public Health, 21
  • [40] THE LIMITATIONS OF BREAST-CANCER SCREENING FOR FIRST-DEGREE RELATIVES OF BREAST-CANCER PATIENTS
    NEUGUT, AI
    JACOBSON, JS
    AMERICAN JOURNAL OF PUBLIC HEALTH, 1995, 85 (06) : 832 - 834
12345