Gastric Cancer Screening in First-Degree Relatives: A Pilot Study in a Diverse Integrated Healthcare System

被引：6
|
作者：
Dong, Elizabeth Y. Y. [1 ]
Giap, Andrew Q. [2 ]
Lustigova, Eva [3 ]
Wu, Bechien U. U. [1 ,3 ,4 ]
机构：
[1] Southern Calif Permanente Med Grp, Div Gastroenterol, Los Angeles, CA 90034 USA
[2] Southern Calif Permanente Med Grp, Div Gastroenterol, Anaheim, CA USA
[3] Southern Calif Permanente Med Grp, Dept Res & Evaluat, Pasadena, CA 90034 USA
[4] Southern Calif Med Grp, Div Gastroenterol, Ctr Pancreat Care, Los Angeles, CA 90034 USA
来源：
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY | 2022年 / 13卷 / 11期
关键词：
INTESTINAL METAPLASIA; RISK;
D O I：
10.14309/ctg.0000000000000531
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
INTRODUCTIONFamily history of gastric cancer has been shown as an independent risk factor of gastric cancer development and is associated with increased risk of progression to gastric cancer among patients with gastric intestinal metaplasia (GIM).METHODSBetween 2017 and 2020, we conducted a prospective pilot screening program of patients with a confirmed first-degree relative with gastric cancer to evaluate the feasibility of screening and prevalence of precursor lesions (e.g., GIM or dysplasia) on biopsy.RESULTSA total of 61 patients completed screening by upper endoscopy with a mapping biopsy protocol: 27 (44%) were found to have GIM and 4 (7%) were found with low-grade dysplasia.DISCUSSIONOur pilot screening program identified a high prevalence of precursor lesions for gastric cancer among asymptomatic patients with a first-degree relative with gastric cancer. Careful endoscopic inspection and standardized biopsy protocols may aid in prompt identification of these precursor lesions in those at risk of gastric cancer.
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页数：2
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