Regioselective Synthesis of Benzimidazolones via Cascade C-N Coupling of Monosubstituted Ureas

被引：25
|
作者：
Ernst, Johannes B. [1 ]
Tay, Nicholas E. S. [1 ]
Jui, Nathan T. [1 ]
Buchwald, Stephen L. [1 ]
机构：
[1] MIT, Dept Chem, Cambridge, MA 02139 USA
来源：
ORGANIC LETTERS | 2014年 / 16卷 / 14期
基金：
美国国家卫生研究院;
关键词：
CATALYZED INTRAMOLECULAR CYCLIZATION; SUBSTITUTED 1,3-DIHYDROBENZIMIDAZOL-2-ONES; INHIBITORS; SERIES; HETEROCYCLES; DERIVATIVES; ANTAGONIST; AMINATION; DISCOVERY; ARYLATION;
D O I：
10.1021/ol501531q
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A direct method for the regioselective construction of benzimidazolones is reported wherein a single palladium catalyst is employed to couple monosubstituted urea substrates with differentially substituted 1,2-dihaloaromatic systems. In this method, the catalyst is able to promote a cascade of two discrete chemoselective C-N bond-forming processes that allows the highly selective and predictable formation of complex heterocycles from simple, readily available starting materials.
引用
收藏
页码：3844 / 3846
页数：3
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