Synthesis of 2′,3′-cyclohexen bicyclic uridine analogues using ring-closure metathesis

被引：6

作者：

Drone, Jullien

Egorov, Maxim

Hatton, Wilfried

Bertrand, Marie-Jo

Len, Christophe

Lebreton, Jacques

机构：

[1] Univ Nantes, CNRS, UMR 6513, Synth Organ Lab, F-44322 Nantes 3, France

[2] Univ Poitiers, CNRS, UMR 6514, FR 2703, F-86022 Poitiers, France

来源：

SYNLETT | 2006年 / 09期

关键词：

antivirals; nucleic acid analogues; radical allylation; ring-closure metathesis;

D O I：

10.1055/s-2006-941568

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of two new 2',3'-cyclohexen bicyclic uridine analogues is described. From 5'-protected uridine two successive tin radical-mediated allylations at 2'-C and 3'-C position followed by ring-closure olefin metathesis on the diene intermediate using Grubbs' catalyst led to the formation of the six-membered ring.

引用

页码：1339 / 1342

页数：4

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