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Formulations for delivery of therapeutic proteins
被引:46
|作者:
Stolnik, Snjezana
[1
]
Shakesheff, Kevin
[1
]
机构:
[1] Univ Nottingham, Sch Pharm, Drug Delivery & Tissue Engn Div, Nottingham NG7 2RD, England
关键词:
Drug delivery;
Intracellular delivery;
Non-invasive;
Protein delivery;
Sustained release;
FORMING DRUG-DELIVERY;
INTRACELLULAR DELIVERY;
CONTROLLED-RELEASE;
NASAL DELIVERY;
PEPTIDE;
SCAFFOLDS;
TRANSPORT;
HYDROGELS;
NANOPARTICLES;
TRANSDUCTION;
D O I:
10.1007/s10529-008-9834-y
中图分类号:
Q81 [生物工程学(生物技术)];
Q93 [微生物学];
学科分类号:
071005 ;
0836 ;
090102 ;
100705 ;
摘要:
Advances in biotechnology have now created a capacity to produce therapeutically active proteins on a commercial scale, opening the potential for their application in an array of disease conditions. The process of translation of the variety of different therapeutic proteins into the medicines used in clinics is now occurring. To assist in this translation, new formulations to deliver proteins could play an important role. These new formulations need to more adequately address the pharmacological and therapeutic requirement for each particular protein/peptide and, in that way, either improve present therapies or extend with new entries the current list of protein based medicines used in clinic.
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页码:1 / 11
页数:11
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