Design, Synthesis and Antiviral Activity Studies of Schizonepetin Derivatives

被引：1
|
作者：
Bao, Beihua [1 ]
Meng, Zheng [1 ]
Li, Nianguang [1 ]
Meng, Zhengjie [2 ]
Zhang, Li [1 ]
Cao, Yudan [1 ]
Yao, Weifeng [1 ]
Shan, Mingqiu [1 ]
Ding, Anwei [1 ]
机构：
[1] Nanjing Univ Chinese Med, Coll Pharm, Jiangsu Key Lab High Technol TCM Formulae Res, Nanjing 210023, Jiangsu, Peoples R China
[2] Nanjing Univ Technol, Coll Biotechnol & Pharmaceut Engn, Nanjing 211816, Jiangsu, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2013年 / 14卷 / 08期
关键词：
schizonepetin; anti-virus activity; HSV-1; H3N2; HERPES-SIMPLEX-VIRUS; PATIENT; RATS;
D O I：
10.3390/ijms140817193
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A series of schizonepetin derivatives have been designed and synthesized in order to obtain potent antivirus agents. The antiviral activity against HSV-1 and influenza virus H3N2 as well as the cytotoxicity of these derivatives was evaluated by using cytopathic effect (CPE) inhibition assay in vitro. Compounds M2, M4, M5 and M34 showed higher inhibitory activity against HSV-1 virus with the TC50 values being in micromole. Compounds M28, M33, and M35 showed higher inhibitory activity against influenza virus H3N2 with their TC50 values being 96.4, 71.0 and 75.4 M, respectively. Preliminary biological activity evaluation indicated that the anti-H3N2 and anti-HSV-1 activities improved obviously through the introduction of halogen into the structure of schizonepetin.
引用
收藏
页码：17193 / 17203
页数：11
相关论文
共 50 条
  • [41] Synthesis, Spectral Characterization, Docking Studies and Antiviral Activity of Phosphorylated Derivatives of Lopinavir Intermediate
    Kuruva, Chandra S.
    Gandavaram, Syam P.
    Shaik, Thaslim B.
    Chintha, Venkataramaiah
    Chamarthi, Naga R.
    Ghosh, Sunil K.
    Wudayagiri, Rajendra
    CHEMISTRYSELECT, 2019, 4 (20): : 6101 - 6105
  • [42] Thiosemicarbazone derivatives: Design, synthesis and in vitro antimalarial activity studies
    Matsa, Ramkishore
    Makam, Parameshwar
    Kaushik, Meenakshi
    Hoti, S. L.
    Kannan, Tharanikkarasu
    EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2019, 137
  • [43] STUDIES ON MECHANISM OF ANTIVIRAL ACTIVITY OF KETOALDEHYDE DERIVATIVES OF BIPHENYL
    MAGRASSI, F
    ALTUCCI, P
    JORI, GP
    LORENZUTTI, G
    SAPIO, U
    TARRO, G
    CHEMOTHERAPY, 1964, 9 (06) : 341 - +
  • [44] STUDIES ON ANTIVIRAL AGENTS .5. SYNTHESIS AND INVITRO ANTIVIRAL ACTIVITY OF NEW AMINOGLYCOSIDE DERIVATIVES HAVING PALMITOYL GROUP
    MATSUDA, K
    YASUDA, N
    TSUTSUMI, H
    TAKAYA, T
    JOURNAL OF ANTIBIOTICS, 1987, 40 (06): : 843 - 854
  • [45] Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities
    Biot, C
    Daher, W
    Chavain, N
    Fandeur, T
    Khalife, J
    Dive, D
    De Clercq, E
    JOURNAL OF MEDICINAL CHEMISTRY, 2006, 49 (09) : 2845 - 2849
  • [46] Design, synthesis, antiviral activities of ferulic acid derivatives
    Mao, Jin-long
    Wang, Lei
    Chen, Shu-jie
    Yan, Bin
    Xun, Li-ying
    Li, Rui-cheng
    Wang, Pei-chen
    Zhao, Qi-tao
    FRONTIERS IN PHARMACOLOGY, 2023, 14
  • [47] Synthesis and Antiviral Activity of Hydrogenated Ferulic Acid Derivatives
    Cui, Can
    Wang, Zhi-Peng
    Du, Xiu-jiang
    Wang, Li-Zhong
    Yu, Shu-Jing
    Liu, Xing-Hai
    Li, Zheng-Ming
    Zhao, Wei-Guang
    JOURNAL OF CHEMISTRY, 2013, 2013
  • [48] Synthesis, antiviral activity and molecular modeling of oxoquinoline derivatives
    Santos, Fernanda da C.
    Abreu, Paula
    Castro, Helena C.
    Paixao, Izabel C. P. P.
    Cirne-Santos, Claudio C.
    Giongo, Viveca
    Barbosa, Juliana E.
    Simonetti, Bruno R.
    Garrido, Valeria
    Bou-Habib, Dumith Chequer
    Silva, David de O.
    Batalha, Pedro N.
    Temerozo, Jairo R.
    Souza, Thiago M.
    Nogueira, Christiane M.
    Cunha, Anna C.
    Rodrigues, Carlos R.
    Ferreira, Vitor F.
    de Souza, Maria C. B. V.
    BIOORGANIC & MEDICINAL CHEMISTRY, 2009, 17 (15) : 5476 - 5481
  • [49] Synthesis and antiviral activity of new pyrazole and thiazole derivatives
    El-Sabbagh, Osama I.
    Baraka, Mohamed M.
    Ibrahim, Samy M.
    Pannecouque, Christophe
    Andrei, Graciela
    Snoeck, Robert
    Balzarini, Jan
    Rashad, Adel A.
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (09) : 3746 - 3753
  • [50] SYNTHESIS AND ANTIVIRAL ACTIVITY EVALUATION OF SOME AMINOADAMANTANE DERIVATIVES
    KOLOCOURIS, N
    FOSCOLOS, GB
    KOLOCOURIS, A
    MARAKOS, P
    POULI, N
    FYTAS, G
    IKEDA, S
    DECLERCQ, E
    JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (18) : 2896 - 2902
12345