Design, Synthesis and Antiviral Activity Studies of Schizonepetin Derivatives

被引：1
|
作者：
Bao, Beihua [1 ]
Meng, Zheng [1 ]
Li, Nianguang [1 ]
Meng, Zhengjie [2 ]
Zhang, Li [1 ]
Cao, Yudan [1 ]
Yao, Weifeng [1 ]
Shan, Mingqiu [1 ]
Ding, Anwei [1 ]
机构：
[1] Nanjing Univ Chinese Med, Coll Pharm, Jiangsu Key Lab High Technol TCM Formulae Res, Nanjing 210023, Jiangsu, Peoples R China
[2] Nanjing Univ Technol, Coll Biotechnol & Pharmaceut Engn, Nanjing 211816, Jiangsu, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2013年 / 14卷 / 08期
关键词：
schizonepetin; anti-virus activity; HSV-1; H3N2; HERPES-SIMPLEX-VIRUS; PATIENT; RATS;
D O I：
10.3390/ijms140817193
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A series of schizonepetin derivatives have been designed and synthesized in order to obtain potent antivirus agents. The antiviral activity against HSV-1 and influenza virus H3N2 as well as the cytotoxicity of these derivatives was evaluated by using cytopathic effect (CPE) inhibition assay in vitro. Compounds M2, M4, M5 and M34 showed higher inhibitory activity against HSV-1 virus with the TC50 values being in micromole. Compounds M28, M33, and M35 showed higher inhibitory activity against influenza virus H3N2 with their TC50 values being 96.4, 71.0 and 75.4 M, respectively. Preliminary biological activity evaluation indicated that the anti-H3N2 and anti-HSV-1 activities improved obviously through the introduction of halogen into the structure of schizonepetin.
引用
收藏
页码：17193 / 17203
页数：11
相关论文
共 50 条
  • [1] Insight into the antiviral activity of synthesized schizonepetin derivatives: A theoretical investigation
    Baghban, Alireza
    Mosavi, Amir
    SCIENTIFIC REPORTS, 2020, 10 (01)
  • [2] Insight into the antiviral activity of synthesized schizonepetin derivatives: A theoretical investigation
    Alireza Baghban
    Amir Mosavi
    Scientific Reports, 10
  • [3] Design, synthesis and antiviral activity of new pyridinone derivatives
    Jourdan, F
    Renault, J
    Fossey, C
    Bureau, R
    Laduree, D
    Robba, M
    Aubertin, AM
    Kirn, A
    ANTIVIRAL CHEMISTRY & CHEMOTHERAPY, 1997, 8 (02): : 161 - 172
  • [4] Studies on synthesis and antiviral activity of ribavirin and its derivatives
    Li, QH
    Li, ZC
    Chen, SH
    Jiang, N
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2004, 24 (11) : 1432 - 1435
  • [5] SYNTHESIS AND STUDIES ON ANTIVIRAL ACTIVITY OF ADAMANTANE THIENYL DERIVATIVES
    VLASOVA, ZV
    BELENKAYA, RS
    LIPKIN, AE
    MOISEEV, IK
    TIMOFEEVA, MM
    BOREKO, EI
    KHIMIKO-FARMATSEVTICHESKII ZHURNAL, 1982, 16 (07): : 808 - 810
  • [6] SYNTHESIS AND STUDIES ON THE ANTIVIRAL ACTIVITY OF CYCLOHEXANE EPOXY AND AZIDO DERIVATIVES
    MUKHAMEDOVA, LA
    GILMANOVA, GK
    KUDRYAVTSEVA, MI
    NASYBULLINA, FG
    KIREEVA, AS
    KHIMIKO-FARMATSEVTICHESKII ZHURNAL, 1982, 16 (07): : 786 - 791
  • [7] Design, synthesis, antiviral activity and cytotoxicity of novel sulphonamide derivatives
    Selvam, P.
    Smee, D. F.
    Gowen, B. B.
    Day, C. W.
    Barnard, D. L.
    Morrey, J. D.
    ANTIVIRAL RESEARCH, 2007, 74 (03) : A81 - A81
  • [8] Design, synthesis and antiviral activity of indole derivatives containing quinoline moiety
    He, Bangcan
    Hu, Yuzhi
    Qin, Yishan
    Zhang, Yufang
    Luo, Xingping
    Wang, Zhenchao
    Xue, Wei
    MOLECULAR DIVERSITY, 2025, 29 (02) : 1091 - 1107
  • [9] Flavonol Derivatives Containing a Quinazolinone Moiety: Design, Synthesis, and Antiviral Activity
    Gong, Chenyu
    Meng, Kaini
    Sun, Zhiling
    Zeng, Wei
    An, Youshan
    Zou, Hongqian
    Qiu, Yujiao
    Liu, Da
    Xue, Wei
    CHEMISTRY & BIODIVERSITY, 2024, 21 (02)
  • [10] STUDIES ON ANTIVIRAL AGENTS .1. SYNTHESIS AND INVITRO ANTIVIRAL ACTIVITY OF NEW KANAMYCIN A DERIVATIVES
    MATSUDA, K
    YASUDA, N
    TSUTSUMI, H
    TAKAYA, T
    JOURNAL OF ANTIBIOTICS, 1985, 38 (04): : 547 - 549
12345