Age-specific effects of noradrenergic alpha-2 agonist clonidine on the development of amygdaloid kindling in developing rats

被引：8
|
作者：
Yoshioka, S [1 ]
Mitani, H [1 ]
Maeda, K [1 ]
Takeo, S [1 ]
Matsuda, K [1 ]
Katayama, S [1 ]
Mizukawa, R [1 ]
Kawahara, R [1 ]
机构：
[1] Tottori Univ, Fac Med, Dept Neuropsychiat, Yonago, Tottori 6830826, Japan
来源：
DEVELOPMENTAL BRAIN RESEARCH | 2000年 / 119卷 / 02期
关键词：
alpha-2; adrenoceptor; clonidine; amygdaloid kindling; ontogenesis; rat;
D O I：
10.1016/S0165-3806(99)00179-0
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The effects of clonidine on the development of amygdaloid kindling were studied in rats of various ages (14, 21, 28 and 70 postnatal days). Administration of clonidine (0.2, 0.5 mg/kg i.p.) caused a significant retardation of kindling development in the 28-day-old rats as well as in the adult rats, whereas, in the 14-day-old rats, the development of kindling was significantly facilitated by clonidine. No significant effect of clonidine was observed in the 21-day-old rats. These results indicate that in rats the effects of clonidine on the development of amygdaloid kindling vary during development. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：283 / 288
页数：6
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