Anti-adalimumab antibodies in juvenile idiopathic arthritis: frequent association with loss of response

被引：30
|
作者：
Skrabl-Baumgartner, A. [1 ]
Erwa, W. [2 ]
Muntean, W. [1 ]
Jahnel, J. [1 ]
机构：
[1] Med Univ Graz, Dept Paediat & Adolescent Med, Auenbruggerpl 34-2, A-8036 Graz, Austria
[2] Med Univ Graz, Inst Med & Chem Lab Diagnost, A-8036 Graz, Austria
来源：
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY | 2015年 / 44卷 / 05期
关键词：
DISEASE-ACTIVITY SCORE; RHEUMATOID-ARTHRITIS; PEDIATRIC-PATIENTS; IMMUNOGENICITY; METHOTREXATE; EFFICACY; AGENTS;
D O I：
10.3109/03009742.2015.1022213
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objectives: We aimed to determine how loss of response (LOR) to adalimumab (ADA) in juvenile idiopathic arthritis (JIA) may be related to anti-ADA antibodies (AAA). Method: AAA and ADA levels were measured in 23 consecutive patients with JIA responding significantly to treatment with ADA. Results: Six out of 23 (26%) patients developed AAA and had low ADA levels. Five out of six AAA-positive patients experienced LOR. In these patients use of concomitant methotrexate (MTX) was significantly lower. Conclusions: The occurrence of AAA is a frequent event associated with LOR. Monitoring of AAA and serum ADA levels should be considered in JIA patients under ADA therapy.
引用
收藏
页码：359 / 362
页数：4
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