Natural product-based design, synthesis and biological evaluation of anthra[2,1-d]thiazole-6,11-dione derivatives from rhein as novel antitumour agents

被引：22

作者：

Liang, Yu-Kun ^{[1
,2
]}

Yue, Zhi-Zhou ^{[1
]}

Li, Jia-Xin ^{[2
]}

Tan, Cun ^{[2
]}

Miao, Ze-Hong ^{[2
]}

Tan, Wen-Fu ^{[3
]}

Yang, Chun-Hao ^{[2
]}

机构：

[1] Wuhan Univ Technol, Sch Chem Engn, Dept Pharmaceut Engn, Wuhan 430070, Hunan, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst MateriaMed, State Key Lab Drug Res, Shanghai 201203, Peoples R China

[3] Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2014年 / 84卷

关键词：

Rhein analogues; Anthra[2,1-d]thiazole-6,11-dione; Antitumour; SRB assay; DRUG DISCOVERY; EVOLVING ROLE; DNA-BINDING; CHEMISTRY; ANALOGS; CYTOTOXICITY; APOPTOSIS;

D O I：

10.1016/j.ejmech.2014.07.047

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two series of novel 2-substituted 5,7-dihydroxyanthra[2,1-d]thiazole-6,11-dione derivatives from natural rhein were designed, synthesized and evaluated for their antitumour activities against human cancer cell lines A549 and HeLa in vitro. (C) 2014 Elsevier Masson SAS. All rights reserved.

引用

页码：505 / 515

页数：11

共 44 条

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