A New Megastigmane Glucoside and Other Constituents from Desmodium gangeticum

被引：6
|
作者：
Hau Viet Dang [1 ]
Giang Hoang Do [1 ]
Phuong Thi Ngo [2 ]
Tien Dat Nguyen [1 ]
Ha Minh Le [2 ]
机构：
[1] Vietnam Acad Sci & Technol VAST, Ctr Res & Technol Transfer, 18 Hoang Quoc Viet, Hanoi, Vietnam
[2] Vietnam Acad Sci & Technol VAST, Inst Nat Prod Chem, 18 Hoang Quoc Viet, Hanoi, Vietnam
来源：
JOURNAL OF CHEMISTRY | 2020年 / 2020卷
关键词：
NITRIC-OXIDE PRODUCTION; PHENOLIC-COMPOUNDS;
D O I：
10.1155/2020/7416973
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new megastigmane glycoside, gangeticoside (1), and three known compounds leonuriside A (2), methyl benzoate 2-O-beta-D-glucopyranoside (3), and tortoside A (4) were isolated from the aerial part of Desmodium gangeticum. Their structures were determined by 1D and 2D NMR spectra. The isolated compounds were evaluated for their inhibitory effect on NO production in LPS-stimulated RAW264.7 cells. Among them, compounds 1, 2, and 3 exhibited strong effect with the IC50 values of 22.3, 15.6, 7.3 mu M, respectively.
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页数：4
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