Highly stereoselective allylic alkylations of peptides

被引：52
|
作者：
Kazmaier, Uli [1 ]
Deska, Jan [1 ]
Watzke, Anja [1 ]
机构：
[1] Univ Saarland, Inst Organ Chem, D-66123 Saarbrucken, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 29期
关键词：
allylation; asymmetric synthesis; chelates; palladium; peptides;
D O I：
10.1002/anie.200600509
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Help from the neighbors: Palladium-catalyzed allylic alkylations are extremely suitable for the stereoselective introduction of unsaturated side chains to peptides (see scheme; TFA = trifluoroacetate). The chiral information of the peptide can be used to control the formation of the new stereogenic center. In general, S amino acids induce the formation of R-configured amino acids. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
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页码：4855 / 4858
页数：4
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