A Simple Synthesis of Densely Substituted Benzofurans by Domino Reaction of 2-Hydroxybenzyl Alcohols with 2-Substituted Furans

被引：10

作者：

Makarov, Anton S. ^{[1
]}

Kekhvaeva, Anna E. ^{[1
]}

Chalikidi, Petrakis N. ^{[2
]}

Abaev, Vladimir T. ^{[2
]}

Trushkov, Igor, V ^{[3
,4
]}

Uchuskin, Maxim G. ^{[1
]}

机构：

[1] Perm State Univ, Bukireva St 15, Perm 614990, Russia

[2] KL Khetagurov North Ossetian State Univ, Vatutina St 46, Vladikavkaz 362025, Russia

[3] Dmitry Rogachev Natl Res Ctr Pediat Hematol Oncol, Samory Mashela St 1, Moscow 117997, Russia

[4] Russian Acad Sci, ND Zelinsky Inst Organ Chem, Leninsky Pr 47, Moscow 119991, Russia

来源：

SYNTHESIS-STUTTGART | 2019年 / 51卷 / 19期

基金：

俄罗斯科学基金会;

关键词：

furan; benzofuran; rearrangement; sugikurojinol B; ONE-POT SYNTHESIS; POLYSUBSTITUTED FURANS; OXIDATIVE CYCLIZATION; INHIBITOR; PALLADIUM; ALKYNYLPHENOLS; DERIVATIVES; DISCOVERY; REUPTAKE; INDOLES;

D O I：

10.1055/s-0039-1690000

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Bro''nsted acid-catalyzed cascade synthesis of densely substituted benzofurans from easily available salicyl alcohols and biomass-derived furans has been developed. The disclosed sequence includes the intermediate formation of 2-(2-hydroxybenzyl)furans that quickly rearrange into functionalized benzofurans. The established protocol was applied for the total synthesis of sugikurojinol B.

引用

页码：3747 / 3757

页数：11

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