Effects of food supplements on periodontal status and local and systemic inflammation after nonoperative periodontal treatment

The present study aimed to assess the effects of a multimicronutrient food supplement on periodontal clinical parameters and systemic/local inflammatory markers. Thirty patients with severe chronic periodontitis who adhered to the Mediterranean diet (MD) underwent non-surgical therapy and daily took either the micronutrient complex (group-A) or olive oil (group-B) from baseline (TO) to 3 months (T2). Supragingival debridement was performed at TO. One month later (T1), one-stage-full-mouth disinfection was performed. Periodontal clinical parameters were monitored and correlated with serum C-reactive protein (CRP) and salivary matrix metalloproteinase-8/9 (MMP5-8/9) quantified at each time point. Longitudinal analysis revealed that in group-A, the MMP-8/-9 levels were decreased at T2 compared with at TO (P= 0.013 and P= 0.004, respectively) and that the MMP-9 levels were decreased at T1 (P = UMW). These reductions were not significant in group-B. The CRP levels in both groups did not Correspondence to Dr. Giulio Rasperini, Department of Biomedical, Surgical and Dental Sciences, University of Milan, Via Commenda 10, 20100 Milan, Italy Fax: +39-0523-335523 E-mail: giulio@studiorasperini.it J-STAGE Advance Publication: March 30, 2019 Color figures can be viewed in the online issue at J-STAGE. doi.org/10.2334/josnusd.18-0048 DN/JST.JSTAGE/josnusd/18-0048 change over time. No between-group differences were noted for any parameter. The correlation between the full-mouth bleeding score and the MMP-8 level in both groups was significant (P < 0.001). The investigated local and systemic inflammatory parameters were not affected by the tested multimicronutrient supplement in patients who adhered to MD. In conclusion, MMP-8 is useful for assessing the reduction in periodontal inflammation.