Netting neutrophils in autoimmune small-vessel vasculitis

被引：1273

作者：

Kessenbrock, Kai ^{[1
,2
]}

Krumbholz, Markus ^{[1
,3
]}

Schoenermarck, Ulf ^{[4
]}

Back, Walter ^{[5
]}

Gross, Wolfgang L. ^{[6
,7
]}

Werb, Zena ^{[2
]}

Groene, Hermann-Josef ^{[8
]}

Brinkmann, Volker ^{[9
]}

Jenne, Dieter E. ^{[1
]}

机构：

[1] Max Planck Inst Neurobiol, Dept Neuroimmunol, Martinsried, Germany

[2] Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA

[3] Univ Munich, Inst Clin Neuroimmunol, Munich, Germany

[4] Univ Hosp Grosshadern, Med Clin 1, Div Nephrol, Munich, Germany

[5] Univ Heidelberg, Mannheim Clin, Dept Pathol, D-6800 Mannheim, Germany

[6] Med Univ Lubeck, Univ Klinikum Schleswig Holstein, Vasculitis Ctr, Dept Rheumatol, D-23538 Lubeck, Germany

[7] Rheumaklin Bad Bramstedt, Lubeck, Germany

[8] German Canc Res Ctr, Dept Cellular & Mol Pathol, D-6900 Heidelberg, Germany

[9] Max Planck Inst Infect Biol, Microscopy Core Facil, Berlin, Germany

来源：

NATURE MEDICINE | 2009年 / 15卷 / 06期

基金：

美国国家卫生研究院;

关键词：

ANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODIES; EXTRACELLULAR TRAPS; DNA; MYELOPEROXIDASE; CELLS;

D O I：

10.1038/nm.1959

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Small-vessel vasculitis (SVV) is a chronic autoinflammatory condition linked to antineutrophil cytoplasm autoantibodies (ANCAs). Here we show that chromatin fibers, so-called neutrophil extracellular traps (NETs), are released by ANCA-stimulated neutrophils and contain the targeted autoantigens proteinase-3 (PR3) and myeloperoxidase (MPO). Deposition of NETs in inflamed kidneys and circulating MPO-DNA complexes suggest that NET formation triggers vasculitis and promotes the autoimmune response against neutrophil components in individuals with SVV.

引用

页码：623 / 625

页数：3

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