Effect of insulin resistance on hepatic function in type 2 diabetes

被引：0
|
作者：
El Oudi, M. [1 ]
Ouertani, H. [2 ]
Aouni, Z. [1 ]
Mazigh, C. [1 ]
Zidi, B. [2 ]
Machghoul, S. [1 ]
机构：
[1] Hop Mil Principal Instruct Tunis, Dept Biochim, Tunis, Tunisia
[2] Hop Mil Principal Instruct Tunis, Dept Endocrinol, Tunis, Tunisia
来源：
IMMUNO-ANALYSE & BIOLOGIE SPECIALISEE | 2009年 / 24卷 / 03期
关键词：
Type; 2; diabetes; Hepatic enzymes; Insulin resistance; ALANINE AMINOTRANSFERASE;
D O I：
10.1016/j.immbio.2009.03.001
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Introduction. - Nowadays the role of liver in the development of type 2 diabetes presents an interest in the recent studies research. Objectives. - In the present study we intend to determine the relationship between hepatic enzymes and insulinresistance in type 2 diabetic patients. Material and method. - The study group consists of 68 diabetics subdivided into two sub-groups: insulinsensitive diabetics (n = 26) and insulin resistant diabetics (n = 42) and a group of 24 control subjects. Results. - Diabetics have significant elevated levels of Alat (p = 0.03), Asat (p = 0.02) and GGT (p = 0.03) when compared to control subjects. Insulinresistant diabetics present the highest levels of hepatic enzymes Asat, Alat and GGT when compared to insulinsensitive diabetics. Conclusion. - Insuline may play a role in the hepatic function. (C) 2009 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：121 / 125
页数：5
相关论文
共 50 条
  • [31] PPARs, insulin resistance and type 2 diabetes
    Kaplan, F
    Al-Majali, K
    Betteridge, DJ
    JOURNAL OF CARDIOVASCULAR RISK, 2001, 8 (04): : 211 - 217
  • [32] Insulin resistance and hyerfiltration in type 2 diabetes
    Zaletel, Jelka
    Pongrac, Drazenka
    Prezelj, Janez
    Remuzzi, Giuseppe
    DIABETES, 2006, 55 : A185 - A185
  • [33] Arrestin' insulin resistance and type 2 diabetes
    Bulletin of the Chinese Academy of Sciences, 2009, (02) : 66 - 67
  • [34] Insulin resistance and type 2 diabetes in children
    Castorani, Valeria
    Polidori, Nella
    Giannini, Cosimo
    Blasetti, Annalisa
    Chiarelli, Francesco
    ANNALS OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, 2020, 25 (04) : 217 - 226
  • [35] Insulin resistance underlying type 2 diabetes
    Lima, Luis Mauricio T. R.
    LANCET DIABETES & ENDOCRINOLOGY, 2019, 7 (06): : 424 - 424
  • [36] Insulin Resistance, Type 2 Diabetes and Atherosclerosis
    Roever, L.
    Casella-Filho, A.
    Dourado, P. M. M.
    Resende, E. S.
    Chagas, A. C. P.
    JOURNAL OF DIABETES & METABOLISM, 2014, 5 (12)
  • [37] Impaired hepatic insulin extraction in type 2 diabetes
    Piccinini, F.
    Man, C. Dalla
    Vella, A.
    Cobelli, C.
    DIABETOLOGIA, 2014, 57 : S236 - S236
  • [38] Increased liver fat, impaired insulin clearance, and hepatic and adipose tissue insulin resistance in type 2 diabetes
    Kotronen, Anna
    Juurinen, Leena
    Tiikkainen, Mirja
    Vehkavaara, Satu
    Yki-Jarvinen, Hannele
    GASTROENTEROLOGY, 2008, 135 (01) : 122 - 130
  • [39] Hepatic insulin resistance after pancreas transplantation in type I diabetes
    Rooney, DP
    Robertson, RP
    DIABETES, 1996, 45 (02) : 134 - 138
  • [40] YOUTH WITH TYPE 1 DIABETES HAVE HEPATIC AND PERIPHERAL INSULIN RESISTANCE
    Stuppy, J. J.
    Green, M.
    Bergman, B.
    Coe, G.
    Baumgartner, A.
    Bacon, S.
    Sherzinger, A.
    Pyle, L.
    Nadeau, K. J.
    JOURNAL OF INVESTIGATIVE MEDICINE, 2017, 65 (01) : 201 - 201
12345