Effect of insulin resistance on hepatic function in type 2 diabetes

被引：0
|
作者：
El Oudi, M. [1 ]
Ouertani, H. [2 ]
Aouni, Z. [1 ]
Mazigh, C. [1 ]
Zidi, B. [2 ]
Machghoul, S. [1 ]
机构：
[1] Hop Mil Principal Instruct Tunis, Dept Biochim, Tunis, Tunisia
[2] Hop Mil Principal Instruct Tunis, Dept Endocrinol, Tunis, Tunisia
来源：
IMMUNO-ANALYSE & BIOLOGIE SPECIALISEE | 2009年 / 24卷 / 03期
关键词：
Type; 2; diabetes; Hepatic enzymes; Insulin resistance; ALANINE AMINOTRANSFERASE;
D O I：
10.1016/j.immbio.2009.03.001
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Introduction. - Nowadays the role of liver in the development of type 2 diabetes presents an interest in the recent studies research. Objectives. - In the present study we intend to determine the relationship between hepatic enzymes and insulinresistance in type 2 diabetic patients. Material and method. - The study group consists of 68 diabetics subdivided into two sub-groups: insulinsensitive diabetics (n = 26) and insulin resistant diabetics (n = 42) and a group of 24 control subjects. Results. - Diabetics have significant elevated levels of Alat (p = 0.03), Asat (p = 0.02) and GGT (p = 0.03) when compared to control subjects. Insulinresistant diabetics present the highest levels of hepatic enzymes Asat, Alat and GGT when compared to insulinsensitive diabetics. Conclusion. - Insuline may play a role in the hepatic function. (C) 2009 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：121 / 125
页数：5
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