Cocoa Phytochemicals: Recent Advances in Molecular Mechanisms on Health

被引：62

作者：

Kim, Jiyoung ^{[1
,2
,3
]}

Kim, Jaekyoon ^{[1
]}

Shim, Jaesung ^{[1
]}

Lee, Chang Yong ^{[4
]}

Lee, Ki Won ^{[1
,2
,3
,5
]}

Lee, Hyong Joo ^{[1
,2
,3
]}

机构：

[1] Seoul Natl Univ, Dept Agr Biotechnol, Seoul 151742, South Korea

[2] Seoul Natl Univ, Ctr Food & Bioconvergence Technol, Seoul 151921, South Korea

[3] Seoul Natl Univ, Adv Inst Convergence Technol, Suwon 443270, Gyeonggi Do, South Korea

[4] Cornell Univ, Dept Food Sci, Geneva, NY 14456 USA

[5] Seoul Natl Univ, Inst Green Bio Sci & Technol, Res Inst Bio Food Ind, Pyeongchang 232916, South Korea

来源：

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION | 2014年 / 54卷 / 11期

基金：

新加坡国家研究基金会;

关键词：

Cocoa; cardiovascular diseases; cancer; neurodegeneration; obesity and diabetes; skin aging; FLAVANOL-RICH COCOA; CACAO LIQUOR PROANTHOCYANIDINS; LOW-DENSITY-LIPOPROTEIN; IMPROVES ENDOTHELIAL FUNCTION; LDL OXIDATIVE SUSCEPTIBILITY; CORONARY-HEART-DISEASE; NF-KAPPA-B; DARK CHOCOLATE; THEOBROMA-CACAO; BLOOD-PRESSURE;

D O I：

10.1080/10408398.2011.641041

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Recent reports on cocoa are appealing in that a food commonly consumed for pure pleasure might also bring tangible benefits for human health. Cocoa consumption is correlated with reduced health risks of cardiovascular diseases, hypertension, atherosclerosis, and cancer, and the health-promoting effects of cocoa are mediated by cocoa-driven phytochemicals. Cocoa is rich in procyanidins, theobromine, (-)-epicatechin, catechins, and caffeine. Among the phytochemicals present in consumed cocoa, theobromine is most available in human plasma, followed by caffeine, (-)-epicatechin, catechin, and procyanidins. It has been reported that cocoa phytochemicals specifically modulate or interact with specific molecular targets linked to the pathogenesis of chronic human diseases, including cardiovascular diseases, cancer, neurodegenerative diseases, obesity, diabetes, and skin aging. This review summarizes comprehensive recent findings on the beneficial actions of cocoa-driven phytochemicals in molecular mechanisms of human health.

引用

页码：1458 / 1472

页数：15

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