Thiourea-based gemfibrozil analogues as HDL-elevating agents

被引：8
|
作者：
Coppola, GM
Damon, RE
Eskesen, JB
France, DS
Paterniti, JR
机构：
[1] Novartis Inst Biomed Res, Dept Metab & Cardiovasc Dis, Summit, NJ 07901 USA
[2] Amylin Pharmaceut, San Diego, CA 92121 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 17期
关键词：
D O I：
10.1016/S0960-894X(02)00435-3
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of gemfibrozil analogues with a thiourea moiety embedded in the side chain was prepared and evaluated as HDL-elevating agents. Derivatives 8b, 9b, 9c, and 9d were found to be approximately as effective as gemfibrozil (1) for HDL cholesterol elevation. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：2439 / 2442
页数：4
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