Understanding the Pro/N-end rule pathway

被引：17
|
作者：
Dougan, David A. [1 ]
Varshavsky, Alexander [2 ]
机构：
[1] La Trobe Univ, La Trobe Inst Mol Sci, Melbourne, Vic, Australia
[2] CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USA
来源：
NATURE CHEMICAL BIOLOGY | 2018年 / 14卷 / 05期
关键词：
DEGRADATION; PROTEIN;
D O I：
10.1038/s41589-018-0045-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Regulated destruction of proteins underlies just about everything a cell does. A structural study of human Gid4, the N-recognin of the Pro/N-end rule pathway that targets proteins through their N-terminal proline, illuminates the recognition of substrates by this proteolytic system.
引用
收藏
页码：415 / 416
页数：3
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