The N-end rule pathway of protein degradation

被引：263

作者：

Varshavsky, A ^{[1
]}

机构：

[1] CALTECH,DIV BIOL,PASADENA,CA 91125

来源：

GENES TO CELLS | 1997年 / 2卷 / 01期

关键词：

D O I：

10.1046/j.1365-2443.1997.1020301.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue. Similar but distinct versions of the N-end rule operate in all organisms examined, from mammals to fungi and bacteria. In eukaryotes, the N-end rule pathway is a part of the ubiquitin system. Ubiquitin is a 76-residue protein whose covalent conjugation to other proteins plays a role in many biological processes, including cell growth and differentiation. I discuss the current understanding of the N-end rule pathway.

引用

页码：13 / 28

页数：16

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