The N-end rule pathway of protein degradation

被引：263
|
作者：
Varshavsky, A [1 ]
机构：
[1] CALTECH,DIV BIOL,PASADENA,CA 91125
来源：
GENES TO CELLS | 1997年 / 2卷 / 01期
关键词：
D O I：
10.1046/j.1365-2443.1997.1020301.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue. Similar but distinct versions of the N-end rule operate in all organisms examined, from mammals to fungi and bacteria. In eukaryotes, the N-end rule pathway is a part of the ubiquitin system. Ubiquitin is a 76-residue protein whose covalent conjugation to other proteins plays a role in many biological processes, including cell growth and differentiation. I discuss the current understanding of the N-end rule pathway.
引用
收藏
页码：13 / 28
页数：16
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