Rheumatoid Arthritis - A Model of Systemic Inflammation Driving Atherosclerosis

被引：132

作者：

Ku, Ivy A. ^{[1
,2
]}

Imboden, John B. ^{[3
]}

Hsue, Priscilla Y. ^{[1
,2
]}

Ganz, Peter ^{[1
,2
]}

机构：

[1] San Francisco Gen Hosp, Div Cardiol, San Francisco, CA 94110 USA

[2] San Francisco Gen Hosp, Ctr Excellence Vasc Res, San Francisco, CA 94110 USA

[3] Univ Calif San Francisco, San Francisco Gen Hosp, Div Rheumatol, San Francisco, CA USA

来源：

CIRCULATION JOURNAL | 2009年 / 73卷 / 06期

关键词：

Atherosclerosis; Coronary artery disease; Inflammation; Rheumatoid arthritis; TUMOR-NECROSIS-FACTOR; ENDOTHELIAL PROGENITOR CELLS; CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN; CARDIOVASCULAR RISK-FACTORS; FACTOR-ALPHA THERAPY; CONVERTING ENZYME-INHIBITION; ACUTE MYOCARDIAL-INFARCTION; HIGH-DENSITY-LIPOPROTEIN; POPULATION-BASED COHORT;

D O I：

10.1253/circj.CJ-09-0274

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Similarities between the inflammatory pathways in atherosclerosis and rheumatoid arthritis (RA) are striking. Chronic systemic inflammation in RA patients leads to cardiovascular (CV) events beyond traditional cardiac risk factors. Clinicians typically focus on treating the joint manifestations of RA while neglecting to eliminate systemic inflammation, which leaves RA patients vulnerable to adverse CV events. In this review we provide an understanding of how systemic inflammation in RA accelerates atherosclerosis. This knowledge should guide therapeutic targets to minimize CV risk in RA, and may lead to insights into the inflammatory mechanisms of atherosclerosis in general. (Circ J 2009; 73: 977-985)

引用

页码：977 / 985

页数：9

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