Antitumor Activity of 6-(cyclohexylamino)-1,3-dimethyl-5(2-pyridyl)furo[2,3-d]pyrimidine-2,4(1H,3H)-dione and Its Ti(IV), Zn(II), Fe(III), and Pd(II) Complexes on K562 and Jurkat Cell Lines

被引：10

作者：

Shabani, Fahmideh ^{[2
]}

Ghammamy, Shahriar ^{[1
]}

Mehrani, Khayroallah ^{[2
]}

Teimouri, Mohammad Bagher ^{[3
]}

Soleimani, Masoud ^{[4
]}

Kaviani, Saeid ^{[4
]}

机构：

[1] Imam Khomeini Int Univ, Fac Sci, Dept Chem, Ghazvin 3414916818, Iran

[2] Islamic Azad Univ, Ardabil Branch, Dept Chem, Young Researchers Club, Ardebil 5615731567, Iran

[3] Iran Polymer & Petrochem Inst, Petrochem Dept, Tehran, Iran

[4] Tarbiat Modares Univ, Fac Med, Dept Hematol, Tehran, Iran

来源：

BIOINORGANIC CHEMISTRY AND APPLICATIONS | 2008年 / 2008卷

关键词：

D O I：

10.1155/2008/501021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

(6-(cyclohexylamino)-1,3-dimethyl-5(2-pyridyl)furo[2,3-d]pyrimidine-2,4(1H,3H)-dione) abbreviated as CDP was synthesized and characterized. Ti(IV), Zn(II), Fe(III), and Pd(II) metal complexes of this ligand are prepared by the reaction of salts of Ti(IV), Zn(II), Fe(III), and Pd(II) with CDP in acetonitrile. Characterization of the ligand and its complexes was made by microanalyses, FT-IR, H-1 NMR, C-13 NMR, and UV-Visible spectroscopy. All complexes were characterized by several techniques using elemental analysis (C, H, N), FT-IR, electronic spectra, and molar conductance measurements. The elemental analysis data suggest the stoichiometry to be 1: 1 [M: L] ratio formation. The molar conductance measurements reveal the presence of 1: 1 electrolytic nature complexes. These new complexes showed excellent antitumor activity against two kinds of cancer cells that are K562 (human chronic myeloid leukemia) cells and Jurkat (human T lymphocyte carcinoma) cells. Copyright (C) 2008 Fahmideh Shabani et al.

引用

页数：5

共 38 条

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[22] Efficient Synthesis of New Pyrimido[5′,4′:5,6]pyrano[2,3-d]pyrimidine-2,4,6(1H,3H)-triones via the Tandem Intramolecular Pinner–Dimroth Rearrangement, and Their Antibacterial Activity
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[23] Synthesis, spectral and single crystal X-ray characterization of 5-(2-(2,3-dimethyl-5-oxo-1-phenyl-2,5-dihydro-1H-pyrazol-4-yl)hydrazono)pyrimidine-2,4,6(1H,3H,5H)-trione and its copper(II) complexes
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[24] Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione Derivative Inhibits d-Dopachrome Tautomerase Activity and Suppresses the Proliferation of Non-Small Cell Lung Cancer Cells (vol 65, pg 2059, 2022)
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[25] An expedient approach for the regioselective synthesis of novel 1,5,6,7-tetrahydro-2H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione derivatives via Fe (III)-mediated iodocyclization
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[26] An efficient p-TSA catalyzed synthesis of some new substituted- (5-hydroxy-3-phenylisoxazol-4-yl)-1,3-dimethyl-1 H-chromeno[2,3-d] pyrimidine-2,4(3H,5H)-dione/3,3-dimethyl-2H-xanthen-1(9H)-one scaffolds and evaluation of their pharmacological and computational investigations
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[27] Novel photo-induced oxidative cyclization of 1,3-dimethyl-5-(1-arylmethylidene)pyrimidine-2,4,6(1,3,5H)-triones:: synthesis and properties of areno[5,6]pyrano[2,3-d]pyrimidine-2,4(1,3H)-dionylium ions and their photo-induced autorecycling oxidizing reaction toward some amines
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[28] Efficient Synthesis of New Pyrimido[5,4:5,6]pyrano[2,3-d]pyrimidine-2,4,6(1H,3H)-triones via the Tandem Intramolecular Pinner-Dimroth Rearrangement, and Their Antibacterial Activity
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[29] Quantum chemical insight into the molecular structure of L-chemosensor 1,3-dimethyl-5-(thien-2-ylmethylene)-pyrimidine-2,4,6-(1H, 3H, 5H)-trione: Naked-eye colorimetric detection of copper(II) anions
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