Alterations in the expression of the DNA repair/redox enzyme APE/ref-1 in epithelial ovarian cancers

被引：0

作者：

Moore, D ^{[1
]}

Michael, H ^{[1
]}

Tritt, R ^{[1
]}

Kelley, M ^{[1
]}

机构：

[1] Indiana Univ, Sch Med, Dept Obstet & Gynecol, Indianapolis, IN 46204 USA

来源：

7TH BIENNIAL MEETING OF THE INTERNATIONAL GYNECOLOGIC CANCER SOCIETY | 1999年

关键词：

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The DNA base excision repair (BER) pathway is responsible for the repair of cellular alkylation and oxidative DNA damage. A crucial step in the BER pathway involves the cleavage of an apurinic/apyrimidinic site in DNA by an AP endonuclease. The major AP endonuclease in mammalian cells is APE/ref-1. We studied the expression of APE/ref-1 in formalin-fixed, paraffin-embedded ovarian tissue specimens using polyclonal and monoclonal antibodies to APE/ref-1. Compared to normal ovarian tissues, benign neoplastic conditions, and low malignant potential tumors, APE/ref-1 immunoreactivity is altered in malignant ovarian tumors. Further studies will determine if the altered expression reflects changes in DNA repair capabilities or redox regulatory functions.

引用

页码：263 / 267

页数：5

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