Alterations in the expression of the DNA repair/redox enzyme APE/ref-1 in epithelial ovarian cancers

被引：0
|
作者：
Moore, D [1 ]
Michael, H [1 ]
Tritt, R [1 ]
Kelley, M [1 ]
机构：
[1] Indiana Univ, Sch Med, Dept Obstet & Gynecol, Indianapolis, IN 46204 USA
来源：
7TH BIENNIAL MEETING OF THE INTERNATIONAL GYNECOLOGIC CANCER SOCIETY | 1999年
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中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The DNA base excision repair (BER) pathway is responsible for the repair of cellular alkylation and oxidative DNA damage. A crucial step in the BER pathway involves the cleavage of an apurinic/apyrimidinic site in DNA by an AP endonuclease. The major AP endonuclease in mammalian cells is APE/ref-1. We studied the expression of APE/ref-1 in formalin-fixed, paraffin-embedded ovarian tissue specimens using polyclonal and monoclonal antibodies to APE/ref-1. Compared to normal ovarian tissues, benign neoplastic conditions, and low malignant potential tumors, APE/ref-1 immunoreactivity is altered in malignant ovarian tumors. Further studies will determine if the altered expression reflects changes in DNA repair capabilities or redox regulatory functions.
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页码：263 / 267
页数：5
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