Direct Access for the Regio- and Stereoselective Synthesis of N-Alkenylpyrazoles and Chromenopyrazoles

被引：14

作者：

Kurma, Siva Hariprasad ^{[1
,2
]}

Sridhar, Balasubramanian ^{[3
]}

Bhimapaka, China Raju ^{[1
,2
]}

机构：

[1] CSIR Indian Inst Chem Technol, Dept Organ Synth & Proc Chem, Hyderabad 500007, India

[2] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India

[3] CSIR Indian Inst Chem Technol, Dept Analyt & Struct Chem, Hyderabad 500007, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 86卷 / 03期

关键词：

ONE-POT SYNTHESIS; REGIOSELECTIVE SYNTHESIS; FACILE SYNTHESIS; PYRAZOLES; HYDRAZONES; ALKYNES; TOSYLHYDRAZONES; DERIVATIVES; HYDRAZIDES; COMPLEXES;

D O I：

10.1021/acs.joc.0c02421

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly regio- and stereoselective method was developed for the preparation of N-alkenylpyrazoles and chromenopyrazoles by the reaction of N-tosylhydrazones and salicyl N-tosylhydrazones with alkynes under neat conditions in the presence of La(OTf)(3). The present study was found to be efficient and convenient for direct access to N-alkenylpyrazoles and chromenopyrazoles through C-C, C-N, and C-O bond forming reactions. Structure assignment of N-alkenylpyrazole compound 5c was confirmed by X-ray analysis.

引用

页码：2271 / 2282

页数：12

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