The Development of a Cat Model of Retinal Detachment and Re-attachment

被引：2

作者：

Wassmer, Sarah ^{[1
,2
]}

Leonard, Brian C. ^{[1
,3
]}

Coupland, Stuart G. ^{[1
,2
,3
]}

Baker, Adam ^{[1
]}

Hamilton, John ^{[1
]}

Torlone, Renee ^{[4
]}

Zacks, David N. ^{[5
]}

Tsilfidis, Catherine ^{[1
,2
,3
]}

机构：

[1] Ottawa Hosp, Res Inst, Regenerat Med, Ottawa, ON K1H 8L6, Canada

[2] Univ Ottawa, Dept Cellular & Mol Med, Ottawa, ON K1H 8M5, Canada

[3] Univ Ottawa, Dept Ophthalmol, Ottawa, ON K1H 8M5, Canada

[4] Ottawa Hosp, Gen Div, Inst Eye, Ottawa, ON K1H 8L6, Canada

[5] Univ Michigan, Sch Med, Dept Ophthalmol & Visual Sci, Kellogg Eye Ctr, Ann Arbor, MI 48105 USA

来源：

RETINAL DEGENERATIVE DISEASES: MECHANISMS AND EXPERIMENTAL THERAPY | 2016年 / 854卷

关键词：

Retinal detachment; Feline; Lensectomy; Vitrectomy; C3F8 gas (Octafluoropropane); Subretinal space; Photoreceptor; Hemorrhage; CELLS; DOGS;

D O I：

10.1007/978-3-319-17121-0_42

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We present an optimized surgical technique for feline retinal detachment which allows for natural re-attachment, reduces retinal scarring and vitreal bands, and allows central placement of the detachment in close proximity to the optic nerve. This enables imaging via Optical Coherence Tomography (OCT) and multifocal electroretinography (mfERG) analysis. Ideal detachment conditions involve a lensectomy followed by a three-port pars plana vitrectomy. A 16-20 % retinal detachment is induced by injecting 8 % C3F8 gas into the subretinal space in the central retina with a 42G cannula. The retinal detachment resolves approximately 6 weeks post-surgery. Imaging is enhanced by using a 7.5 and 20 diopter lens for OCT and mfERG fundus imaging, respectively, to compensate for the removed lens.

引用

页码：315 / 321

页数：7

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