Diversity-oriented fluorescence library approach for the discovery of sensors and probes

被引：69

作者：

Lee, Jun-Seok ^{[1
,2
]}

Kim, Yun Kyung ^{[1
,2
]}

Vendrell, Marc ^{[3
]}

Chang, Young-Tae ^{[1
,3
]}

机构：

[1] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore

[2] NYU, Dept Chem, New York, NY 10003 USA

[3] ASTAR, Lab Bioimaging Probe Dev, Singapore Bioimaging Consortium SBIC, Singapore 138667, Singapore

来源：

MOLECULAR BIOSYSTEMS | 2009年 / 5卷 / 05期

关键词：

SOLID-PHASE SYNTHESIS; MOLECULAR-WEIGHT HEPARIN; COMBINATORIAL DISCOVERY; SPECTRAL PROPERTIES; DYES; RNA; BINDING; FLUOROPHORES; CHEMOSENSORS; EVENTS;

D O I：

10.1039/b821766c

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fluorescent small molecules have received considerable attention due to their potential for chemosensing and bioimaging. A conventional strategy for probe development is a target-oriented approach based on known molecular recognition mechanisms for individual analytes. However, sophisticated rational design does not always guarantee the applicability of probes in complex biological systems. Therefore the speed and the scope of sensor development has been limited. To overcome these limitations, diversity-oriented fluorescence library approaches have been applied to develop new fluorescent probes in the absence of knowledge about the target recognition mechanism. This review summarizes recent advances in fluorescent probe development facilitated by diversity-oriented library approaches.

引用

页码：411 / 421

页数：11

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