Rhodium-Catalyzed Asymmetric Conjugate Alkynylation of Enones with Alkynylsilanols

被引：47
|
作者：
Nishimura, Takahiro [1 ]
Tokuji, Sumito [1 ]
Sawano, Takahiro [1 ]
Hayashi, Tamio [1 ]
机构：
[1] Kyoto Univ, Grad Sch Sci, Dept Chem, Sakyo Ku, Kyoto 6068502, Japan
来源：
ORGANIC LETTERS | 2009年 / 11卷 / 15期
关键词：
BOND-FORMING REACTIONS; CHIRAL DIENE LIGANDS; HECK-TYPE REACTION; TERMINAL ALKYNES; ALPHA; BETA-UNSATURATED KETONES; STEERING LIGANDS; ACTIVATED KETONES; 1,4-ADDITION; ADDITIONS; ALDEHYDES;
D O I：
10.1021/ol901119d
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Asymmetric conjugate alkynylation of alpha,beta-unsaturated ketones with (triisopropylsilyl)ethynylsilanols giving beta-alkynylketones took place in high yields with high enantioselectivity in the presence of chiral rhodium catalysts.
引用
收藏
页码：3222 / 3225
页数：4
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