An efficient synthesis of novel pyrano[2,3-d]- and furopyrano[2,3-d]pyrimidines via indium-catalyzed multi-component domino reaction

被引：33

作者：

Prajapati, Dipak ^{[1
]}

Gohain, Mukut ^{[1
]}

机构：

[1] Reg Res Lab, Dept Med Chem, Jorhat, Assam, India

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 2卷

关键词：

D O I：

10.1186/1860-5397-2-11

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Various novel pyrano [2,3-d] pyrimidines 5 and furopyrano [2,3-d] pyrimidines 7 were synthesized in 80-99% yields via a multicomponent domino Knoevenagel/ hetero-Diels-Alder reaction of 1,3dimethyl barbituric acid with an aromatic aldehyde and ethyl vinyl ether/2,3-dihydrofuran in presence of 1 mol% of indium(III) chloride. The reaction also proceeds in aqueous media without using any catalyst, but the yield is comparatively less (65-70%).

引用

页数：4

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