Leonuketal, a Spiroketal Diterpenoid from Leonurus japonicus

被引：53

作者：

Xiong, Liang ^{[1
,2
]}

Zhou, Qin-Mei ^{[1
,2
]}

Zou, Yike ^{[3
]}

Chen, Ming-Hua ^{[4
,5
]}

Guo, Li ^{[1
,2
]}

Hu, Guan-Ying ^{[1
,2
]}

Liu, Zhao-Hua ^{[6
]}

Peng, Cheng ^{[1
,2
]}

机构：

[1] Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 611137, Peoples R China

[2] Chengdu Univ Tradit Chinese Med, State Key Lab Breeding Base Systemat Res Dev & Ut, Chengdu 611137, Peoples R China

[3] Univ Penn, Dept Chem, Philadelphia, PA 19104 USA

[4] Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China

[5] Peking Union Med Coll, Beijing 100050, Peoples R China

[6] Chengdu 1 Pharmaceut Co Ltd, Chengdu 610031, Peoples R China

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 24期

基金：

中国博士后科学基金;

关键词：

TRITERPENOIDS;

D O I：

10.1021/acs.orglett.5b03227

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An architecturally complex spiroketal diterpenoid, leonuketal (1), was isolated from the aerial parts of the plant Leonurus japonicus. This compound possessed an unprecedented tetracyclic skeleton that comprised a bridged spiroketal moiety fused with a ketal-gamma-lactone unit. The structure and absolute configuration were determined by spectroscopic analyses, a modified Moshers method, and ECD (electronic circular dichroism) calculations. Leonuketal (1) showed significant vasorelaxant activity against KCl-induced contraction of rat aorta, with the EC50 value of 2.32 mu M.

引用

页码：6238 / 6241

页数：4

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