Leonuketal, a Spiroketal Diterpenoid from Leonurus japonicus

被引：53
|
作者：
Xiong, Liang [1 ,2 ]
Zhou, Qin-Mei [1 ,2 ]
Zou, Yike [3 ]
Chen, Ming-Hua [4 ,5 ]
Guo, Li [1 ,2 ]
Hu, Guan-Ying [1 ,2 ]
Liu, Zhao-Hua [6 ]
Peng, Cheng [1 ,2 ]
机构：
[1] Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 611137, Peoples R China
[2] Chengdu Univ Tradit Chinese Med, State Key Lab Breeding Base Systemat Res Dev & Ut, Chengdu 611137, Peoples R China
[3] Univ Penn, Dept Chem, Philadelphia, PA 19104 USA
[4] Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China
[5] Peking Union Med Coll, Beijing 100050, Peoples R China
[6] Chengdu 1 Pharmaceut Co Ltd, Chengdu 610031, Peoples R China
来源：
ORGANIC LETTERS | 2015年 / 17卷 / 24期
基金：
中国博士后科学基金;
关键词：
TRITERPENOIDS;
D O I：
10.1021/acs.orglett.5b03227
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An architecturally complex spiroketal diterpenoid, leonuketal (1), was isolated from the aerial parts of the plant Leonurus japonicus. This compound possessed an unprecedented tetracyclic skeleton that comprised a bridged spiroketal moiety fused with a ketal-gamma-lactone unit. The structure and absolute configuration were determined by spectroscopic analyses, a modified Moshers method, and ECD (electronic circular dichroism) calculations. Leonuketal (1) showed significant vasorelaxant activity against KCl-induced contraction of rat aorta, with the EC50 value of 2.32 mu M.
引用
收藏
页码：6238 / 6241
页数：4
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