Are urinary PAHs biomarkers of controlled exposure to diesel exhaust?

被引：10

作者：

Lu, Sixin S. ^{[1
]}

Sobus, Jon R. ^{[2
]}

Sallsten, Gerd ^{[3
]}

Albin, Maria ^{[4
]}

Pleil, Joachim D. ^{[2
]}

Gudmundsson, Anders ^{[4
]}

Madden, Michael C. ^{[5
]}

Strandberg, Bo ^{[3
]}

Wierzbicka, Aneta ^{[4
]}

Rappaport, Stephen M. ^{[6
]}

机构：

[1] Univ Calif Berkeley, Coll Nat Resources, Berkeley, CA 94720 USA

[2] US EPA, Human Exposure & Atmospher Sci Div, Natl Exposure Res Lab, Res Triangle Pk, NC 27711 USA

[3] Univ Gothenburg, Gothenburg, Sweden

[4] Lund Univ, S-22100 Lund, Sweden

[5] US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA

[6] Univ Calif Berkeley, Sch Publ Hlth, Ctr Exposure Biol, Berkeley, CA 94720 USA

来源：

BIOMARKERS | 2014年 / 19卷 / 04期

基金：

瑞典研究理事会; 美国国家科学基金会;

关键词：

Biomarker; diesel exhaust; PAHs; polycyclic aromatic hydrocarbons; urine; POLYCYCLIC AROMATIC-HYDROCARBONS; SOLID-PHASE MICROEXTRACTION; WORKERS; ENGINE;

D O I：

10.3109/1354750X.2014.910553

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Urinary polycyclic aromatic hydrocarbons (PAHs) were evaluated as possible biomarkers of exposure to diesel exhaust (DE) in two controlled-chamber studies. We report levels of 14 PAHs from 28 subjects in urine that were collected before, immediately after and the morning after exposure. Using linear mixed-effects models, we tested for effects of DE exposure and several covariates (time, age, gender and urinary creatinine) on urinary PAH levels. DE exposures did not significantly alter urinary PAH levels. We conclude that urinary PAHs are not promising biomarkers of short-term exposures to DE in the range of 106-276 mu g/m(3).

引用

页码：332 / 339

页数：8

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