CanDIG: Federated network across Canada for multi-omic and health data discovery and analysis

被引：11

作者：

Dursi, L. Jonathan ^{[1
]}

Bozoky, Zoltan ^{[2
]}

de Borja, Richard ^{[3
,13
]}

Li, Haoyuan ^{[4
]}

Bujold, David ^{[5
]}

Lipski, Adam ^{[4
,6
]}

Rashid, Shaikh Farhan ^{[1
]}

Sethi, Amanjeev ^{[1
]}

Memon, Neelam ^{[4
]}

Naidoo, Dashaylan ^{[4
,24
]}

Coral-Sasso, Felipe ^{[4
]}

Wong, Matthew ^{[7
]}

Quirion, P-O ^{[5
]}

Lu, Zhibin ^{[8
]}

Agarwal, Samarth ^{[9
]}

Pavlov, Yuriy ^{[1
]}

Ponomarev, Andrew ^{[4
,10
]}

Husic, Mia ^{[11
]}

Pace, Krista ^{[1
]}

Palmer, Samantha ^{[1
]}

Grover, Stephanie A. ^{[12
]}

Hakgor, Sevan ^{[13
]}

Siu, Lillian L. ^{[13
]}

Malkin, David ^{[14
]}

Virtanen, Carl

Pugh, Trevor J. ^{[3
,13
,15
]}

Jacques, Pierre-Etienne ^{[16
]}

Joly, Yann ^{[17
,18
]}

Jones, Steven J. M. ^{[4
,19
]}

Bourque, Guillaume ^{[18
,20
,21
]}

Brudno, Michael ^{[1
,22
,23
]}

机构：

[1] Univ Hlth Network, DATA Team, Toronto, ON M5G 2C4, Canada

[2] Providence Hlth Care, Vancouver, BC V6Z 1Y6, Canada

[3] Ontario Inst Canc Res, Toronto, ON M5G 0A3, Canada

[4] BC Canc Res Inst, Canadas Michael Smith Genome Sci Ctr, Prov Hlth Serv Author, Vancouver, BC V5Z 4S6, Canada

[5] Canadian Ctr Computat Genom, Montreal, PQ H3A 0G1, Canada

[6] Zymeworks, Vancouver, BC V6H 3V9, Canada

[7] Univ Waterloo, Waterloo, ON N2L 3G1, Canada

[8] Univ Hlth Network, Toronto, ON M5G 2C4, Canada

[9] Univ Toronto, Toronto, ON M5T 3A1, Canada

[10] GenX, Nottingham NG1 1GF, England

[11] Hosp Sick Children, Ctr Computat Med, Toronto, ON M5G 1X8, Canada

[12] Univ Toronto, Hosp Sick Children, Genet & Genome Biol Program, Toronto, ON M5G 1X8, Canada

[13] Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON M5G 2C1, Canada

[14] Univ Toronto, Hosp Sick Children, Dept Pediat, Div Haematol Oncol, Toronto, ON M5G 1X8, Canada

[15] Univ Toronto, Dept Med Biophys, Toronto, ON M5G 1L7, Canada

[16] Univ Sherbrooke, Dept Biol, Sherbrooke, PQ J1K 2R1, Canada

[17] McGill Univ, Ctr Genom & Policy, Dept Human Genet, Montreal, PQ H3A 0C7, Canada

[18] McGill Univ, Dept Human Genet, Montreal, PQ H3A 0C7, Canada

[19] Univ British Columbia, Dept Med Genet, Columbia, BC V6H 3N1, Canada

[20] McGill Univ, Canadian Ctr Computat Genom C3G, Montreal, PQ H3A 0G1, Canada

[21] McGill Univ, Fac Med, McGill Genome Ctr, Montreal, PQ H3A 0G1, Canada

[22] Univ Toronto, Dept Comp Sci, Toronto, ON M5T 3A1, Canada

[23] Vector Inst, Toronto, ON M5G 1M1, Canada

[24] Providence Hlth & Serv, Mol Genom Lab, Portland, OR USA

来源：

CELL GENOMICS | 2021年 / 1卷 / 02期

基金：

加拿大创新基金会;

关键词：

D O I：

10.1016/j.xgen.2021.100033

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We present the Canadian Distributed Infrastructure for Genomics (CanDIG) platform, which enables federated querying and analysis of human genomics and linked biomedical data. CanDIG leverages the standards and frameworks of the Global Alliance for Genomics and Health (GA4GH) and currently hosts data for five pan-Canadian projects. We describe CanDIG's key design decisions and features as a guide for other federated data systems.

引用

页数：7

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