Cancer Stem Cells in Squamous Cell Carcinoma

被引：26
|
作者：
Jian, Zhe [1 ,2 ]
Strait, Alexander [1 ]
Jimeno, Antonio [3 ]
Wang, Xiao-Jing [1 ]
机构：
[1] Univ Colorado Denver, Dept Pathol, Anschutz Med Campus,Bldg RC1-N,RoomP18-5128, Aurora, CO 80045 USA
[2] Fourth Mil Med Univ, Xijing Hosp, Dept Dermatol, Xian, Shaanxi, Peoples R China
[3] Univ Colorado Denver, Div Med Oncol, Dept Med, Anschutz Med Campus, Aurora, CO USA
来源：
JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2017年 / 137卷 / 01期
基金：
中国国家自然科学基金;
关键词：
SIDE POPULATION CELLS; HAIR FOLLICLE BULGE; HEMATOPOIETIC STEM; SKIN-CANCER; METASTATIC CAPACITY; SOMATIC MUTATIONS; SELF-RENEWAL; NECK-CANCER; TGF-BETA; HEAD;
D O I：
10.1016/j.jid.2016.07.033
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Cancer stem cells (CSCs) are found in many cancer types, including squamous cell carcinoma (SCC). CSCs initiate cancer formation and are linked to metastasis and resistance to therapies. Studies have revealed that several distinct CSC populations coexist in SCC and that tumor initiation and metastatic potential of these populations can be uncoupled. Therefore, it is critical to understand CSC biology to develop novel CSC-targeted therapies for patients with SCC with poor prognoses. This review compares the properties of CSCs in SCC with normal stem cells in the skin, summarizes current advances and characteristics of CSCs, and considers the challenges for CSC-targeted treatment of SCC.
引用
收藏
页码：31 / 37
页数：7
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