Sphingosine 1-phosphate: A Potential Molecular Target for Ovarian Cancer Therapy?

被引：30

作者：

Dai, Lan ^{[1
,2
]}

Xia, Pu ^{[3
]}

Di, Wen ^{[1
,2
]}

机构：

[1] Shanghai Jiao Tong Univ, Renji Hosp, Dept Obstet & Gynecol, Sch Med, Shanghai 200127, Peoples R China

[2] Fudan Univ, Focus Construct Subject Shanghai Educ Dept, Shanghai Key Lab Gynecol Oncol, Shanghai 200433, Peoples R China

[3] Fudan Univ, Zhongshan Hosp, Dept Endocrinol, Shanghai 200433, Peoples R China

来源：

CANCER INVESTIGATION | 2014年 / 32卷 / 03期

关键词：

Ovarian cancer; Sphingosine; 1-phosphate; Sphingosine kinase; ENDOTHELIAL GROWTH-FACTOR; SMOOTH-MUSCLE-CELLS; NECROSIS-FACTOR-ALPHA; UP-REGULATION; TNF-ALPHA; KINASE; SPHINGOSINE-1-PHOSPHATE LYASE; SIGNALING PATHWAY; PROSTATE-CANCER; DOWN-REGULATION;

D O I：

10.3109/07357907.2013.876646

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Sphingosine 1-phosphate (S1P) is an important signaling regulator involved in tumor progression in multiple neoplasms. However, the role of S1P in the pathogenesis of ovarian cancer remains unclear. Herein, we summarize recent advances in understanding the impact of S1P signaling in ovarian cancer progression. S1P, aberrantly produced in ovarian cancer patients, is involved in the regulation of key cellular processes that contribute to ovarian cancer initiation and progression. Moreover, agents that block the S1P signaling pathway inhibit ovarian cancer cell growth or induce apoptosis. Hence, current evidence suggests that S1P may become a potential molecular target for ovarian cancer therapy.

引用

页码：71 / 80

页数：10

共 50 条

[31] Therapeutic potential of targeting sphingosine kinases and sphingosine 1-phosphate in hematological malignancies
Evangelisti, C.
Evangelisti, C.
Buontempo, F.
Lonetti, A.
Orsini, E.
Chiarini, F.
Barata, J. T.
Pyne, S.
Pyne, N. J.
Martelli, A. M.
LEUKEMIA, 2016, 30 (11) : 2142 - 2151
[32] Therapeutic potential of targeting sphingosine kinases and sphingosine 1-phosphate in hematological malignancies
C Evangelisti
C Evangelisti
F Buontempo
A Lonetti
E Orsini
F Chiarini
J T Barata
S Pyne
N J Pyne
A M Martelli
Leukemia, 2016, 30 : 2142 - 2151
[33] Sphingosine Kinase and Sphingosine 1-Phosphate in Cardioprotection
Karliner, Joel S.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2009, 53 (03) : 189 - 197
[34] Sphingosine 1-phosphate signaling
Hla, T.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2009, 7 : 76 - 76
[35] The role of sphingosine 1-phosphate/sphingosine 1-phosphate receptor signaling in the pathogenesis of rheumatoid arthritis
Kitano, M.
Tam, Y. Y.
Sekiguchi, M.
Kuroda, M.
Kuno, H.
Kuroiwa, T.
Hashimoto, N.
Matsui, K.
Iwasaki, T.
Saba, J.
Hla, T.
Sano, H.
ANNALS OF THE RHEUMATIC DISEASES, 2006, 65 : 132 - 132
[36] Potential role of sphingosine 1-phosphate in the pathogenesis of rheumatoid arthritis
Bollag, Wendy B.
JOURNAL OF LIPID RESEARCH, 2008, 49 (11) : 2281 - 2282
[37] A facile regioselective synthesis of sphingosine 1-phosphate and ceramide 1-phosphate
Szulc, ZM
Hannun, YA
Bielawska, A
TETRAHEDRON LETTERS, 2000, 41 (41) : 7821 - 7824
[38] Sphingosine kinase 1 as a potential therapeutic target in epithelial ovarian cancer
Lee, Jeong-Won
Ryu, Ji-Yoon
Yoon, Gun
Jeon, Hye-Kyung
Cho, Young-Jae
Choi, Jung-Joo
Song, Sang Yong
Do, In-Gu
Lee, Yoo-Young
Kim, Tae-Joong
Choi, Chel Hun
Kim, Byoung-Gie
Bae, Duk-Soo
INTERNATIONAL JOURNAL OF CANCER, 2015, 137 (01) : 221 - 229
[39] When the Sphingosine Kinase 1/Sphingosine 1-Phosphate Pathway Meets Hypoxia Signaling: New Targets for Cancer Therapy
Ader, Isabelle
Malavaud, Bernard
Cuvillier, Olivier
CANCER RESEARCH, 2009, 69 (09) : 3723 - 3726
[40] Pharmacological relevance and potential of sphingosine 1-phosphate in the vascular system
Schuchardt, Mirjam
Toelle, Markus
Pruefer, Jasmin
van der Giet, Markus
BRITISH JOURNAL OF PHARMACOLOGY, 2011, 163 (06) : 1140 - 1162

← 1 2 3 4 5 →