Feasibility of Salvage Re-irradiation With Stereotactic Radiotherapy for Recurrent Glioma Using CyberKnife

被引：6
|
作者：
Adachi, Kana [1 ]
Hayashi, Kazuhiko [2 ,3 ]
Kagawa, Naoki [4 ]
Kinoshita, Manabu [4 ]
Sumida, Iori [2 ]
Akino, Yuichi [2 ]
Shiomi, Hiroya [2 ]
Tamari, Keisuke [2 ]
Suzuki, Osamu [2 ]
Hirayama, Ryuichi [4 ]
Kijima, Noriyuki [4 ]
Isohashi, Fumiaki [2 ]
Seo, Yuji [2 ]
Otani, Keisuke [2 ]
Kishima, Haruhiko [4 ]
Ogawa, Kazuhiko [2 ]
机构：
[1] Toyonaka City Hosp, Dept Radiat Oncol, Toyonaka, Osaka, Japan
[2] Osaka Univ, Grad Sch Med, Dept Radiat Oncol, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan
[3] Osaka Heavy Ion Therapy Ctr, Osaka, Japan
[4] Osaka Univ, Grad Sch Med, Dept Neurosurg, Suita, Osaka, Japan
来源：
ANTICANCER RESEARCH | 2019年 / 39卷 / 06期
关键词：
Stereotactic radiotherapy; recurrent glioma; CyberKnife; re-irradiation; safety profile; PROGNOSTIC-FACTORS; RADIOSURGERY; SURVIVAL; THERAPY;
D O I：
10.21873/anticanres.13423
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aim: To evaluate the toxicity and efficacy of re-irradiation with salvage stereotactic radiotherapy (SRT) for recurrent glioma using CyberKnife. Patients and Methods: This study retrospectively investigated 35 patients with 48 recurrent grade 2-4 gliomas who received SRT between 1998 and 2011. Six patients (17.1%) had grade 2 gliomas, nine (25.7%) had grade 3 gliomas, and 20 (57.1%) had glioblastomas; all initially underwent surgery and conventional radiotherapy. The median initial and subsequent radiotherapy doses were 60 and 26 Gy, respectively. Results: After a median follow-up period of 9.0 months, the only toxicity of grade 2 or more was radiation-induced brain necrosis in four patients (11.4%). The median overall and progression-free survival periods following re-irradiation were 9.0 and 3.0 months, respectively. Univariate analysis revealed that performance status at salvage re-irradiation was a significant predictor of progression-free survival. Conclusion: Salvage re-irradiation using CyberKnife is feasible, with an acceptable toxicity profile, for patients with recurrent glioma.
引用
收藏
页码：2935 / 2940
页数：6
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