Topical sirolimus therapy for epidermal nevus with features of acanthosis nigricans

被引：9

作者：

Dodds, Melissa ^{[1
,2
]}

Maguiness, Sheilagh ^{[1
]}

机构：

[1] Univ Minnesota, Dept Dermatol, Div Pediat Dermatol, Minneapolis, MN 55455 USA

[2] Med Coll Wisconsin, Dept Pediat, 8701 Watertown Plank Rd, Milwaukee, WI 53226 USA

来源：

PEDIATRIC DERMATOLOGY | 2019年 / 36卷 / 04期

关键词：

acanthosis nigricans; epidermal nevus; FGFR3; topical sirolimus; GROWTH;

D O I：

10.1111/pde.13833

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

We present a 4-year-old developmentally appropriate boy with short stature and widespread expanding epidermal nevus with features of acanthosis nigricans. He was found to have a mosaic mutation in FGFR3, the R248C variant. Despite several therapies, he continued to have growth, fissuring, and bleeding of the affected skin. Ultimately, topical sirolimus was attempted and found to improve thickness and overall symptoms.

引用

页码：554 / 555

页数：2

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