Topical sirolimus therapy for epidermal nevus with features of acanthosis nigricans

被引：9

作者：

Dodds, Melissa ^{[1
,2
]}

Maguiness, Sheilagh ^{[1
]}

机构：

[1] Univ Minnesota, Dept Dermatol, Div Pediat Dermatol, Minneapolis, MN 55455 USA

[2] Med Coll Wisconsin, Dept Pediat, 8701 Watertown Plank Rd, Milwaukee, WI 53226 USA

来源：

PEDIATRIC DERMATOLOGY | 2019年 / 36卷 / 04期

关键词：

acanthosis nigricans; epidermal nevus; FGFR3; topical sirolimus; GROWTH;

D O I：

10.1111/pde.13833

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

We present a 4-year-old developmentally appropriate boy with short stature and widespread expanding epidermal nevus with features of acanthosis nigricans. He was found to have a mosaic mutation in FGFR3, the R248C variant. Despite several therapies, he continued to have growth, fissuring, and bleeding of the affected skin. Ultimately, topical sirolimus was attempted and found to improve thickness and overall symptoms.

引用

页码：554 / 555

页数：2

共 50 条

[1] The acanthosis nigricans form of epidermal nevus
Ersoy-Evans, Sibel
Sahin, Sedef
Mancini, Anthony J.
Paller, Amy S.
Guitart, Joan
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2006, 55 (04) : 696 - 698
[2] This is linear verrucous epidermal nevus, not acanthosis nigricans
Khunger, Niti
Kathuria, Sushruta
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY, 2010, 63 (04): : E415 - E415
[3] UNILATERAL EPIDERMAL NEVUS RESEMBLING ACANTHOSIS NIGRICANS
CURTH, HO
BRITISH JOURNAL OF DERMATOLOGY, 1976, 95 (04) : 433 - 436
[4] Topical sirolimus therapy for nevus sebaceus and epidermal nevus: A case series
Zhou, Amanda G.
Antaya, Richard J.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2022, 87 (02) : 407 - 409
[5] Nevoid acanthosis nigricans or RAVEN (rounded and velvety epidermal nevus): Three cases
Petit, A.
Lemarchand-Venencie, F.
Pinquier, L.
Lebbe, C.
Bourrat, E.
ANNALES DE DERMATOLOGIE ET DE VENEREOLOGIE, 2012, 139 (03): : 183 - 188
[6] CONCOMITANT BECKER NEVUS AND ACANTHOSIS NIGRICANS
HULSMANS, RFHJ
HULSMANS, FJH
BRITISH JOURNAL OF DERMATOLOGY, 1989, 120 (05) : 716 - 717
[7] Topical therapy with tretinoin and ammonium lactate for acanthosis Nigricans associated with obesity
Blobstein, SH
CUTIS, 2003, 71 (01): : 33 - 34
[8] Successful topical sirolimus treatment of epidermal nevus in a patient with phacomatosis spilosebacea
Morello-Vicente, Ana
Oteiza-Rius, Ines
Salido-Vallejo, Rafael
Antonanzas, Javier
Estenaga, Angela
Pretel, Maider
Aguado, Leyre
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2024, 38 (06) : e507 - e508
[9] Successful Amelioration of Inflammatory Linear Verrucous Epidermal Nevus with Topical Sirolimus
Patel, Nayankumar
Padhiyar, Jignaben
Patel, Ani
Chhibber, Aseem
Patel, Tejas
Patel, Bhagirath
ANNALS OF DERMATOLOGY, 2020, 32 (06) : 534 - 536
[10] Epidermal Insulin Resistance as a Therapeutic Target in Acanthosis Nigricans?
Malisiewicz, Bartosz
Boehncke, Sandra
Lang, Victoria
Boehncke, Wolf-Henning
Buerger, Claudia
ACTA DERMATO-VENEREOLOGICA, 2014, 94 (05) : 607 - 608

← 1 2 3 4 5 →