Neutral and Ionic Cycloruthenated 2-Phenylindoles as Cytotoxic Agents

被引：17
|
作者：
Belsa, Lluis [1 ]
Lopez, Concepcion [1 ]
Gonzalez, Asensio [2 ]
Font-Bardia, Merce [3 ]
Calvet, Teresa [4 ]
Calvis, Carmen [5 ]
Messeguer, Ramon [5 ]
机构：
[1] Univ Barcelona, Fac Quim, Dept Quim Inorgan, E-08028 Barcelona, Spain
[2] Univ Barcelona, Fac Farm, Lab Quim Organ, E-08028 Barcelona, Spain
[3] Univ Barcelona, Ctr Cient & Tecnol, Unitat Difraccio Raig 10, E-08028 Barcelona, Spain
[4] Univ Barcelona, Fac Geol, Dept Crystallog Mineral & Diposits Minerals, E-08028 Barcelona, Spain
[5] LEITAT Tecnol Ctr, Biomed Div, E-08028 Barcelona, Spain
来源：
ORGANOMETALLICS | 2013年 / 32卷 / 24期
关键词：
ESTROGEN-RECEPTOR AFFINITY; PLATINUM COMPLEXES; ARENE COMPLEXES; METAL-COMPLEXES; CELL-CYCLE; IN-VITRO; RUTHENIUM; CANCER; DESIGN; 2-PHENYLINDOLE-3-CARBALDEHYDES;
D O I：
10.1021/om400941b
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The synthesis and characterization of two families of cyclometalated Ru(II) complexes with the new (C-sp2,N-indole)(-) motif formed by activation of the C-H bonds of 2-phenylindole ligands of the general formula {(4'-R'-C6H4)-3-NOMe-5-R-2-6-R-3-(C6H2N)}are presented. The novel ruthenacycles show a remarkable cytotoxic activity in MCF7 and MDA-MB231 breast cancer cell lines, which clearly exceeds those of the trans and cis isomers of [PtCl2(L)(DMSO)] derived from the same ligands and even that of cisplatin.
引用
收藏
页码：7264 / 7267
页数：4
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