Neutral and Ionic Cycloruthenated 2-Phenylindoles as Cytotoxic Agents

被引：17

作者：

Belsa, Lluis ^{[1
]}

Lopez, Concepcion ^{[1
]}

Gonzalez, Asensio ^{[2
]}

Font-Bardia, Merce ^{[3
]}

Calvet, Teresa ^{[4
]}

Calvis, Carmen ^{[5
]}

Messeguer, Ramon ^{[5
]}

机构：

[1] Univ Barcelona, Fac Quim, Dept Quim Inorgan, E-08028 Barcelona, Spain

[2] Univ Barcelona, Fac Farm, Lab Quim Organ, E-08028 Barcelona, Spain

[3] Univ Barcelona, Ctr Cient & Tecnol, Unitat Difraccio Raig 10, E-08028 Barcelona, Spain

[4] Univ Barcelona, Fac Geol, Dept Crystallog Mineral & Diposits Minerals, E-08028 Barcelona, Spain

[5] LEITAT Tecnol Ctr, Biomed Div, E-08028 Barcelona, Spain

来源：

ORGANOMETALLICS | 2013年 / 32卷 / 24期

关键词：

ESTROGEN-RECEPTOR AFFINITY; PLATINUM COMPLEXES; ARENE COMPLEXES; METAL-COMPLEXES; CELL-CYCLE; IN-VITRO; RUTHENIUM; CANCER; DESIGN; 2-PHENYLINDOLE-3-CARBALDEHYDES;

D O I：

10.1021/om400941b

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The synthesis and characterization of two families of cyclometalated Ru(II) complexes with the new (C-sp2,N-indole)(-) motif formed by activation of the C-H bonds of 2-phenylindole ligands of the general formula {(4'-R'-C6H4)-3-NOMe-5-R-2-6-R-3-(C6H2N)}are presented. The novel ruthenacycles show a remarkable cytotoxic activity in MCF7 and MDA-MB231 breast cancer cell lines, which clearly exceeds those of the trans and cis isomers of [PtCl2(L)(DMSO)] derived from the same ligands and even that of cisplatin.

引用

页码：7264 / 7267

页数：4

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