Characterization of the human germ cell nuclear factor gene

被引：30

作者：

Susens, U ^{[1
]}

Borgmeyer, U ^{[1
]}

机构：

[1] UNIV HAMBURG,ZENTRUM MOL NEUROBIOL,D-20251 HAMBURG,GERMANY

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1996年 / 1309卷 / 03期

关键词：

germ cell nuclear factor; nuclear receptor superfamily; expression; testis; neuronal;

D O I：

10.1016/S0167-4781(96)00157-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A cDNA clone encoding the germ cell nuclear factor, GCNF, a member of the nuclear receptor superfamily has been isolated from the human embryonal carcinoma cell line NT2/D1. Sequencing of this clone reveals an open reading frame encoding a 476 amino acid protein. A comparison of the amino acid sequence of the human GCNF with its mouse homologue shows only six amino acid exchanges in the whole protein and a deletion in the amino-terminal region. Northern blot analysis demonstrates that the expression in the testis is conserved.

引用

页码：179 / 182

页数：4

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