An efficient approach to chloro(organophosphine) gold(I) complexes for the synthesis of auranofin

被引：10
|
作者：
Wang, Junchang [1 ]
Mi, Xuemeng [1 ]
Wang, Jiazhe [1 ]
Yang, You [1 ]
机构：
[1] East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, 130 Meilong Rd, Shanghai 200237, Peoples R China
来源：
GREEN CHEMISTRY | 2017年 / 19卷 / 03期
关键词：
GLYCOSYL ORTHO-ALKYNYLBENZOATES; N-HETEROCYCLIC CARBENE; PROPARGYL 1,2-ORTHOESTERS; STEREOSELECTIVE-SYNTHESIS; PHOSPHINE COMPLEXES; ANTITUMOR-ACTIVITY; ANTICANCER; CATALYSIS; DONORS; DRUGS;
D O I：
10.1039/c6gc02908f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A practical and efficient synthesis of chloro(organophosphine) gold(I) complexes is reported. Employment of 4,4'-dihydroxydiphenyl sulfide as a safe and non-irritating reductant is highlighted for the generation of Au(I)-S intermediates, which could be trapped by mono-and bidentate phosphine ligands to provide organophosphine gold(I) complexes. The utility of the present method is further demonstrated by the synthesis of the antiarthritic drug auranofin.
引用
收藏
页码：634 / 637
页数：4
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